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"It is not unusual for some patients to demonstrate depression or sedation when phenobarbital therapy is initiated. This effect is generally transient and resolves as the patient acclimates to the medication. If this problem has not resolved after two weeks, a phenobarbital blood level can be drawn to determine if the dose is too high for the individual in question. Running a blood level sooner may not be useful as it takes a couple of weeks to achieve a stable and meaningful blood level".
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