Agonists vs re-uptake inhibitors?
Are re-uptake inhibitors less likely to reduce long-term depletion of the respective neurotransmitters than agonists? For example do SSRI's reduce long-term depletion levels of serotonin, if so is it less than serotonin agonists do? Same with noradrenaline and dopamine i.e. is Ritalin (a dopamine and noradrenaline re-uptake inhibitor I think) less likely to reduce long-term levels than an agonist of these neurotransmitters (I think amphetamines)?
My logic is if you are inhibiting re-uptake then you are still producing your own neurotransmitters just not losing as much. Whereas when you are giving them to your brain you will start producing less of you own (like steroid users with testosterone).
This is all based on my logic and minimal scientific knowledge so I would be grateful if anyone could give me some information.
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