Well, it really depends. NMDA receptors aren't really well understood. It may be that it requires some specific type o antagonism to achieve that. NMDA receptors aren't all alike. DXM and memantine are both NMDA antagonists but their effects are very different. The former is a powerful hallucinogen and the second has very different effects. Memantine has a much higher specifity for the receptor subtype we'd be looking for. To exemplify this, I mention the fact that to get any significant tolerance-reducing effects with DXM you gotta be tripping balls with it and it's still not as effective as memantine.
There's also an old antibiotic called D-cycloserine, which antagonizes NMDA receptors and has been used succesfully to cure anxiety when administered prior to exposure to anxiety-inducing situations.
Fact is that it may work or not. Only way to find out would be if it were specifically researched for this purpose.
Last edited by etinin; 08-02-2012 at 02:27 AM.
Codein's patient information - "Side effects: ... False sense of well-being."