aspirin and COX enzymes?

[shubhanshu nagar]

Would aspirin be more active if it were to interact with prostaglandins directly rather than by blocking the activity of COX enzymes?

[ladypam]

The action of aspirin is this: Aspirin or Acetyl Salicylic Acid deactivates COX enzymes through the process of acetylation, which is irreversible. Since the COX enzymes are responsible for the production of prostaglandins and other substances responsible for blood clotting, deactivating the COX enzymes also deactivates the production of prostaglandins. In answer to your question, I do not think aspirin can directly affect prostaglandins to make it more active since its direct action is really on COX enyzmes. Since the direct interaction of Aspirins with prostaglandins does not exist, then it does not make it more active. For more info on aspirin, you can check out this site: [url=http://www.medscape.com/viewarticle/507660_2]Log In Problems[/url]