if ur on a low dose of methadone for pain..for 30 days.then get oxycodone..?

[seymour]

10mgs 4 times aday..will it work..being you have methadone in ur systym..and it being a blocker?????????? 10 points explain???????????
i mean not taking the 2 together just the oxycodone!!!!

[Tia]

I have heard it stated before, too, that methadone will "block" any other opiate from working, and it's not true. People who have severe chronic pain issues are sometimes prescribed one of the more potent, long acting meds like methadone, or oxycontin for the chronic, severe pain. And are prescribed Vicodin or another form of hydrocodone or oxycodone for breakthru pain. They *can* work together.

The methadone is to manage your chronic pain. The oxycodone is for times when you have "breakthrough" pain. That is when the pain is severe enough that the methadone is not sufficient. As long as they were both prescribed by your doctor and you follow the label instructions, you should be ok.

[ask_marilynne]

I M P O R T A N T

Please talk to the pharmacist or the doctor who prescribed these dangerous medications.
It is too easy to overdose on these. Please take my recommendation.

Background Information about M E T H A D O N E

Methadone is a rigorously well-tested medication that is safe and efficacious for the treatment of narcotic withdrawal and dependence. For more than 30 years this synthetic narcotic has been used to treat opioid addiction. Heroin releases an excess of dopamine in the body and causes users to need an opiate continuously occupying the opioid receptor in the brain. Methadone occupies this receptor and is the stabilizing factor that permits addicts on methadone to change their behavior and to discontinue heroin use.

Taken orally once a day, methadone suppresses narcotic withdrawal for between 24 and 36 hours. Because methadone is effective in eliminating withdrawal symptoms, it is used in detoxifying opiate addicts. It is, however, only effective in cases of addiction to heroin, morphine, and other opioid drugs, and it is not an effective treatment for other drugs of abuse. Methadone reduces the cravings associated with heroin use and blocks the high from heroin, but it does not provide the euphoric rush. Consequently, methadone patients do not experience the extreme highs and lows that result from the waxing and waning of heroin in blood levels. Ultimately, the patient remains physically dependent on the opioid, but is freed from the uncontrolled, compulsive, and disruptive behavior seen in heroin addicts.

Withdrawal from methadone is much slower than that from heroin. As a result, it is possible to maintain an addict on methadone without harsh side effects. Many MMT patients require continuous treatment, sometimes over a period of years.

Methadone maintenance treatment provides the heroin addict with individualized health care and medically prescribed methadone to relieve withdrawal symptoms, reduces the opiate craving, and brings about a biochemical balance in the body. Important elements in heroin treatment include comprehensive social and rehabilitation services.
------------------------------...
If you have specific questions about methadone that are not answered in our Methadone Fact Sheet, please contact the following agencies:

American Association for the Treatment of Opioid Dependence at http://www.aatod.org/

Center for Substance Abuse Treatment (CSAT) Division of Pharmacologic Therapies at http://dpt.samhsa.gov/

If you are interested in finding a treatment program in your area, please call 800-662-HELP or visit the Treatment Facility Locator Web site.
------------------------------...
Introduction to: O X Y C O D O N E

Oxycodone is a schedule II narcotic analgesic and is widely used in clinical medicine. It is marketed either alone as controlled release (OxyContin®) and immediate release formulations (OxyIR®, OxyFast®), or in combination with other nonnarcotic analgesics such as aspirin (Percodan®) or acetaminophen (Percocet®). The introduction in 1996 of OxyContin®, commonly known on the street as OC, OX, Oxy, Oxycotton, Hillbilly heroin, and kicker, led to a marked escalation of its abuse as reported by drug abuse treatment centers, law enforcement personnel, and health care professionals. Although the diversion and abuse of OxyContin® appeared initially in the eastern U.S., it has now spread to the western U.S. including Alaska and Hawaii. Oxycodone-related adverse health effects increased markedly in recent years. In 2004, Food and Drug Administration (FDA) approved generic forms of controlled release oxycodone products for marketing.

Licit Uses:

Products containing oxycodone in combination with aspirin or acetaminophen are used for the relief of moderate to moderately severe pain. Oxycodone controlled-release tablets are prescribed for the management of moderate to severe pain when a continuous, around-the-clock analgesic is needed for an extended period of time. Oxycodone is a widely prescribed in the U.S. Prescriptions for OxyContin® (1.57 million) and similar controlled release products accounted for 7.6 million of the 42.3 million total prescriptions for oxycodone in 2006 (IMS Health™).

[DynoDiKk]

Here's what you do man. Space that 10mg's four times a day to where your last dose is at 6pm. Get the Melatonin for sleep and contrary to what a nurse told me, TAKE what you need to sleep. A doctor says people have taken up to 100mg's a night to sleep. I doubt you will need that much. In the A.M.Breakthrough.................


Save the Percocets for than so you DO not need to wait an hour for the Methadone to kick in and sit there and suffer. you need to take two, do it!

It is pointless to utilize the Percocets in Conjunction with the Methadone throughout the day. You are gonna need these things in the morning/ I know this will work. This is provided your dosage of Methadone is stable.

And tell these people you again are not on this because your a addict. Yea, the Perc's will work in the AM regardless of what is binding to M1 AND AND AND M2 receptors. To the green and the blue ones too! And pink one's. The Methadone is not gonna be that effecient in a 20mg dose holding out over 12 hours. It is gonna block the highest end that the Oxy would penetrate but on the low end it is gonna work. Trust me. You need this for break-thru and it will work. You aren't taking this stuff for ridiculous cravings!

[ladypam]

Since there are no documented evidence of adverse reactions between methadone and oxycodone, then it will definitely work together safely. Methadone is usually prescribed for chronic pain because it has a longer half life which means it exists in the blood longer. Unfortunately, even if it is in the blood, the concentration is not much to have a significant effect so there is a need to take it 3-4 times a day. Knowing this, your doctor probably prescribed you oxycodone which has a sustained release, giving relief for a longer period of time.

Methadone does not block but competes with glutamate for an NMDA receptor in the brain cells. Glutamate has an excitatory effect on its target organs therefore increasing pain perception. With methadone competing with the same receptor, the amount of glutamate being attached to receptor is lessened, therefore lowering levels of pain.

On the other hand, oxycodone works on the opioid receptors of the brain which inhibits the release of excitatory neurotransmitters like acetylcholine, GABA, noradrenaline, and dopamine, including somatostatin and vasopressin, whose effect is to decrease excitablity in the brain.

So, instead of blocking each other, they actually complement each other in giving relief from pain.

Hope this helps.