Can Tramadol be potentiated by using the certain substances such as Diphenhydramine or Promethazine?

[Danny Havok]

I understand that opiates such as Hydrocodone, Morphine, and Oxycodone can have their effects increased by using certain chemicals such as the ones I named in my question. Would this method still apply to Tramadol, it being a synthetic analouge of codeine? This isn't for abuse purposes, but for the desire to take less medication on a daily basis, due to the overall effects being increased. Thank you very much my friends.

[dbdb1275]

Yes it can, even though it is a synthetic it acts the same as other opiates and will interact or react with most other drugs. You have probably already been told that tramadol is not safe for long term use so please be careful (however not many of the strong pain meds are) Tramadol is not reccomended for use with other drugs like morphine. I know you would like to reduce the amount of medication your on so perhaps morphine patches could help? Good luck : -)