it depends on how much you took before. if you are taking regualr amounts you can alternate the meds every two hours or so. i do it all the time because neither helps my headaches alone.
Do not take aspirin with ibuprofen. NSAIDs, especially ibuprofen, antagonize the antiplatelet and cardioprotective effect of low-dose aspirin. If routine NSAID therapy is necessary, diclofenac may be a viable alternative.
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