How can serotonin reuptake inhibitors and dopamine reuptake inhibitors...

[Luke-a-LO]

...counteract each other? example: How would your body react to the mixture of Focalin (Dexmethylphenidate; a dopamine reuptake inhibitor) and Paxil (Paroxetine; a selective serotonin reuptake inhibitor) ?????

[Simonizer1218]

These two classes of drugs are essentially independent of one another, or at least as far as they can be considering the complexity of the nervous system. What I mean by independent is that dopamine uptake blockers don't usually affect serotonin uptake and vice versa. But, of coursre, serotonin neurons, and dopamine neurons DO communicate with one another, so the combination of the two inhibitors will affect these interactions, and will affect behavior of the subject. But, it's difficult to say in what way.