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Old 04-15-2008
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Is it dangerous to combine a dopamine reuptake inhibitor and a selective serotonin reuptake inhibitor?
Hi, i suffer from obsessive compulsive disorder, and my doctor has prescribed Cilift 20mg, I have been using this medication for 2weeks, but me and my doctor are sure that I suffer from a dopamine deficiency as well, feeling exhausted regardless of how much I sleep, I really struggle to concentrate and I feel empty, no emotion except for anxiety which is caused by the serotonin deficiency. I want to get better asap, so I'm just wondering if combining a serotonin reuptake inhibitor with a dopamine reuptake inhibitor could be dangerous..
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Old 04-17-2008
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Combining a serotonin reuptake inhibitor with a dopamine reuptake inhibitor is safe since they act on two different substances. In fact, tricyclic antidepressants act on both serotonin and dopamine.

A cause for concern is probably the side effects that you may experience from these medications which are sometimes more enhanced due to taking 2 antidepressants. But it is best to consult with your doctor on which medication to take. Hope you feel better soon.
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