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You can definitely stay with him, as long as you are not sick, since the immune system of your brother will be compromised and he is very susceptible to an infection.
It is done intravenously IV. It is not usually painful but they may experience a bit of pain and discomfort when the medication enters the body through IV.
Depending on his disposition and health, he will definitely feel very weak, sometimes nauseous. He can go home after or stay on until he feels a bit stronger.
Hope this helps.
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