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Patients are not given a high dose of Clozapine immediately, rather they are titrated with a gradually increasing dose starting from one-half of a 25-mg tablet (12.5 mg) once or twice daily and then be continued with daily dosage increments of 25-50 mg/day, if well tolerated, to achieve a target dose of 300-450 mg/day by the end of 2 weeks
Dosing should not exceed 900 mg/day.
Of course you cannot do this without doctor's advise since dosage varies from one case to another. it's not like analgesics where you can either take 250mg or 500mg every 6 hours.
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