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Thread: Remicade alternatives

  1. Default Remicade alternatives

    Hi,

    My mother had been receiving Remicade via IV as a treatment for her chronic and advanced rheumatoid arthritis.

    All was going well until earlier this week. She had severe reactions to the drug and as a result will not be able to receive it anymore. She had tightening in her chest, broke out in hives etc.

    She has also tried Metatraxate but this caused even worse reactions.

    Is there anything else that you would recommend trying??


    Thanks.


  2. Remicade (infliximab) is generally a safe and effective treatment for a number of inflammatory conditions, such as Crohn's disease, psoriatic arthritis, and ulcerative colitis. However, not everyone tolerates it well, and in some cases, it may not work as well as expected. In these situations, a healthcare provider may recommend alternatives to Remicade.

    Depending on the condition being treated, these options can include:


    * Other medications, such as corticosteroids, antibiotics, or antidiarrheals
    * Dietary changes
    * Lifestyle changes
    * Nutritional supplementation
    * Surgery.
    Last edited by tinmuning; 10-07-2010 at 07:12 PM. Reason: Removed link in post

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    Quote Originally Posted by Monkey Chunks View Post
    Hi,

    My mother had been receiving Remicade via IV as a treatment for her chronic and advanced rheumatoid arthritis.

    All was going well until earlier this week. She had severe reactions to the drug and as a result will not be able to receive it anymore. She had tightening in her chest, broke out in hives etc.

    She has also tried Metatraxate but this caused even worse reactions.

    Is there anything else that you would recommend trying??


    Thanks.
    Seems that the reaction your mom had is due to allergy to Remicade. Did she see a doctor or got emergency treatment right after the reaction? Only her doctor can recommend an alternative to Remicade or you mother can take pre-meds (i.e. antihistamines) prior to Remicade infusion. You and your mom could probably discuss these possibilities with her doctor.

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    karleluis is offline Banned Reason: Posting unwanted, random content
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    Hi,
    Remicade, also called infliximab, is known as an 'Tumor Necrosis Factor Inhibitor' or TNF and must be given by Intravenous (IV) Injection in a clinic. As would be expected, 17 percent of Remicade patients had infusion reactions requiring half of them to stop treatment. These reactions are fairly common from what I have heard from many people. The main reported side-effect was in 20 percent of those receiving Remicade were diagnosed with skin disorders, such as eczema or psoriasis.

  5. You may want to look into Enbrel or Humira. Enbrel was the first anti-TNF drug and was approved in 1998. Humira is more recent, having been approved in 2002.
    Internationally known, nationally recognized and locally respected.

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    Hi @Monkey Chunks,

    I also have RA - currently the disease is reasonably well suppressed via 'sulfasalazine' and 'hydroxychloroquine' and I have to take 'prednisone/prednisolone' during flare ups. My specialist has suggested that I try 'leflunomide' if things take a turn for the worse, might be worth looking into for your mother.
    Cheers,
    2fortheshow
    Last edited by 2fortheshow; 04-19-2011 at 02:42 AM. Reason: tried adding @ symbol to notify user

  7. #7
    Quote Originally Posted by Bulldog View Post
    You may want to look into Enbrel or Humira. Enbrel was the first anti-TNF drug and was approved in 1998. Humira is more recent, having been approved in 2002.
    There's quite a few anti-TNFs out there now. Some others include Simponi (Golimumab) and Cimzia (Certolizumab --off-label, not indicated for RA).

  8. My mother was also on all the IV drugs like Enbril and Remicade. They seemed to help her for awhile, and then stop working. She did get some sort of blood infection once from Remicade and she ended up getting a recurrence of a cancer that had been in remission for more than 15 years. After she passed away a few years ago, I found that people with a history of cancer should not be on these drugs. I do believe that Remicade brought her cancer back and promoted it. I wish my mom would have tried alternative methods other than these drugs for her arthritis - but I know the pain is really severe for people with rheumatoid arthritis.

    Good luck and I hope you find something else for her.
    Last edited by cyn5; 05-07-2011 at 12:02 AM.

  9. Remicade (infliximab) is a biologic response modifier, specifically a monoclonal antibody which binds to and blocks tumor necrosis factor alpha (TNF-alpha). Tumor necrosis factor (TNF) alpha is a cytokine involved in the inflammatory process.

    Excess TNF-alpha has been blamed for inflammation and joint damage characteristic of rheumatoid arthritis and other forms of inflammatory arthritis.

    What Other Drugs are Similar to Remicade? These are your alternative choices. Speak with your doctor before you change any medications.

    Remicade was the second TNF inhibitor to be approved by the U.S. Food and Drug Administration in 1999.
    Enbrel was the first anti-TNF drug and was approved in 1998.
    Humira was approved in 2002.

  10. Yes! Remicade is generally a safe and effective treatment for a number of inflammatory conditions, such as Crohn's disease, psoriatic arthritis, and ulcerative colitis. However, not everyone tolerates it well, and in some cases, it may not work as well as expected. In these situations,

    Thanks & Regards,

    -------------------------
    hcg diet miami
    Last edited by mavvin; 06-29-2011 at 05:48 PM. Reason: signature link removed

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    Default Remicade Alternatives

    I've had RA for about 5 years and been on several of the meds to include Remicade. It worked wonderfully for me for about 6 months then ended up causing me several skin infections followed by medication induced meningitis which landed me in the hospital and forced me off the drug unfortunately.

    There are several comparable drugs (some of which have already been listed in previous replies) like Orencia for example which is also what is sometimes referred to as a Biologiic.

    Methotrexate (which I'm still taking) is a different level or type of drug used for RA and other autoimmune diseases, as is Plaquenil, and are usually used as the first line of attack or are continued along with some of AntiTNF or Biologics like Remicade, Humira etc.

    There is unfortunately no way at this time to know what medicine will work on what persons autoimmune disease nor for how long each might work for a certain person or who may have - or develop- allergic reactions and/or dangerous side affects down the road.

    It is all actually pretty darn frustrating, but the good news is that there is a lot of research being done in this field right now as it is a leading cause of disability in the US, and new meds are being introduced all the time now. Your mother, or whoever else this might pertain to as well, really needs to work very closely with a good Rheumatologist and that they feel good about, in order to be able to work through the confusing and sometimes scary maze of Autoimmune Diseases like RA, PA, Lupus and a host of others.

    I, myself, have not found my "magic elixir" as of yet since having to come off the Remicade yet, but feel pretty confident tha I will soon so encourage your mother or whoever else this might apply to, to stick in there. A good source of support, encouragement and knowledge is the website I mentioned earlier - Arthritis Insight. I wouldnt have made it through my first horrifying year with this dreadful disease without them. I'm sure there are other valuable ones as well.
    Regards, Melly
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    I have Crohns disease and have had several infusions of remicade. It worked very well for me to control a particular issue arising from my Crohns (an infection that was not responding to antibiotics) and put me in long term remission. When I got the infusions the nurses were very careful to keep me under observation during the infusion and for a couple of hours afterwards because of the risk of adverse reactions even if you have had the drug before. Now that my Crohns is under control my doctor doesn't want me to use remicade unless absolutely necessary because of the risk of an adverse reaction or declining effect, he wants to save it for when its absolutely necessary. So at the moment I take two anti-inflammatories daily: mesalazine and azathioprine. Those drugs seem to be effective to keep me in remission.

    The good news is that new drugs for these conditions are constantly under development and science's understanding of the cause is slowly advancing.

  13. Quote Originally Posted by Monkey Chunks View Post
    Hi,

    My mother had been receiving Remicade via IV as a treatment for her chronic and advanced rheumatoid arthritis.

    All was going well until earlier this week. She had severe reactions to the drug and as a result will not be able to receive it anymore. She had tightening in her chest, broke out in hives etc.

    She has also tried Metatraxate but this caused even worse reactions.

    Is there anything else that you would recommend trying??


    Thanks.
    Infusion reactions aren't uncommon and can usually be controlled by administering a corticosteroid or anti-histamines during the administration of infliximab, so keep that in mind. Sulfasalazine is fairly effective at managing rheumatoid arthritis, assuming your mother hasn't tried it already. Adalimumab and etanercept are options as well and belong to the biologic class of drugs (monoclonal antibodies); both are TNF-alpha inhibitors and are quite similar to infliximab in terms of efficacy and tolerability.
    Last edited by mrdeltoid; 02-01-2012 at 05:00 AM.


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