Does it matter if you take water with Ambien

[marty]

I've read that you should take both Ambien and Xanax with a full galss of water. Why? I've been taking it with Gatorade. Does it really make a difference?

[Mathieu]

Gatorade should be completely fine. Most general information leaflets say to take with a full glass of water because.... nothing.

Don't take it with citrus juice (orange juice, especially grapefruit). The acidity can change rates of absorption and citrus (grapefruit being the worst of them all) can change liver enzymes and completely change the concentration of the drug.

In fact, taking any liquid with a pill is typically not needed (yes, it helps to swallow). But some drugs will have absorption and concentration changes depending on drinking/not drinking and eating/not eating.

Don't worry.