Yes, prednisone is a corticosteroid, which will cause a huge decrease in sperm production. It would be a miracle if you got pregnant while he is on it. My Hubby is suppose to get a steroid shot in his back for a spine problem and we know we won't be able to try for about six months. Steroids can be a shock to the system, no matter if your a boy or a girl taking them. Mosby's drug book has more info on it, you can look it up online. Good luck
