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Medications work best when taken on time. Depending on your daily schedule, if you can manage to be strict on taking them exactly on time, then please do so. It is always hard at first to get into a routine of taking medications. But once you get used to it, it will just be like clockwork to you.
Several minutes before or after the prescribed time will not affect much but forgetting to take it especially if it happens often may lower down its effect.
Hope this helps.
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