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Thread: Will Zoloft really make you gain weight?

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    Jim H's Avatar
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    Default Will Zoloft really make you gain weight?

    My nephew was advised by the doctor to take Zoloft for his anxiety. He has always seemed like a quiet person, taking things seriously, so I'm quite concerned about him.

    That's why I got even more worried when out of the rare instances he spoke, he commented that he might be gaining weight due to the meds, and he dislikes it.

    Does this really happen for Zoloft users?

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    cleo is offline Junior Member
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    I was on that for awhile, but I didn't notice any weight gain. I did, however, had problems with dry mouth.

    Maybe it's something else?

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    This stuff made me gain a LOT of weight. It just comes with the territory though, and it doesn't hit everyone I guess.

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    Paxil (20mg) caused my weight to go up from about 155 to 185 in only 2 years or so with absolutley no change in general diet (this of course led to to high BP, high chlosteral and lots more meds for those conditions). I finally just quit taking everything one day I was so disgusted (had to go back and taper of the paxil over a month) without even talking to my GP. He just couldn't put the 2+2 together. Later I went to specialist (Psych), who suggested zoloft and have been on a low dose of Zoloft (50mg) since without and weight issues. This is just how my body deals with these two SSRI's. Everyone is different and reacts to the different SSRIs differently. I have read alot of stories that people have weight gain issues using zoloft.

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    zoloft is the last medication that i used, i have gained 12 lbs on it, i quit it like 3 weeks ago but i haven't lost even 1 lbs since quitting it so i'm not sure if zoloft had a role in my weight gain but ssris generally cause weight gain.

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    I took Zoloft for many years, and I didnt gain any weight. I guess it depends on on the person. It worked well, but it did not make me gain weight
    Last edited by dixiewolf; 05-25-2011 at 11:30 PM.
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    Zoloft didn't make me gain weight directly, but after taking it for a few weeks I noticed I was eating more than usual. Then my psychiatrist told me that it and other SSRI's can stimulate the appetite. I put 2 and 2 together; Zoloft made me gain weight indirectly.
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    Zoloft was my first AD. When I was on it was the first time that I actually lost any weight (about 10kg in a half a year or so).
    But my loss of weight was probably indirectly linked to zoloft. While on it I had the energy to do stuff and get out of the house.. So for me Zoloft was a great AD in all regards... at least until it stopped working after a year.

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    It affects everyone differently. I gained 7 pounds in a matter of days, and I exercise and watch what I eat very carefully. However, I've had friends who had no problems at all with weight gain. My mood was wonderful, but for me it wasn't worth the weight.

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    Default Anto-Depressants

    I have taken Paxil Zoloft Lexapro and prozac at different time over the years
    ann they all made me gain weight. I think the majority of people on them do. The ones who don't have a different metabilism as it was explained to me.

    I hopr this info helps people who gain weigt either without eating more or those who get hunger cravings (one of the side effects of the drug)

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    Quote Originally Posted by ducttape View Post
    Zoloft was my first AD. When I was on it was the first time that I actually lost any weight (about 10kg in a half a year or so).
    But my loss of weight was probably indirectly linked to zoloft. While on it I had the energy to do stuff and get out of the house.. So for me Zoloft was a great AD in all regards... at least until it stopped working after a year.
    It quit working for me as well (as a lot of AD's do) but I took something else for a couple years and went back to it and it worked again. Now I am on Lexapro. I gained weight initially b/c I lost about 40 pounds from depression, but I needed to gain. For me, it's something I have to take and I have to go to the doctor every few months or so just to see how my current med is doing. I'm used to the process, I have had to take something since I was a teenager.

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    I took Zoloft for about 4 months before switching and it didn't cause any changes in weight. I'm a young man who has a very fast metabolism so my type might be exempt from that sort of side-effect.

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    I don't know if Zoloft causes a lot of weight gain, but it made me so sleepy that I could hardly function during the day. All I wanted to do was sleep and I'm sure the inactivity could add to weight gain. Thus, in a round about way, I suppose if anything causes sluggishness, it could be considered a contributor to gaining weight.
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    I was on a bunch of different AD's until I found one that worked for me without unbearable side effects. Zoloft didn't make me gain weight [and I have a tendency to put it on], but I took a really low dose - 25 mg.

    Paxil piled the pounds on me and a friend who was on it too. A relative was on prozac and buspar, and put on about 50 lbs in 6 months. I think eating as a means to make yourself feel better played a role in her case.

    I have read that there is some evidence that AD's slow metabolism and/or the act of up'ing serotonin causes weight gain.

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    When I took Remeron it made it so I couldn't tell I was full. So I'd keep eating. I'd have to consciouslly measure out portions to avoid overeating and gaining weight.

    The drugs don't actually make you gain weight, the over-eating does. If you can manage to control that, it will be ok. It can be hard at first, but if you're aware of it before you start taking the drug it shouldn't be a problem.

    It would be like saying marijuana makes you gain weight, it doesn't, it just makes you hungry.

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    Quote Originally Posted by akl63 View Post
    When I took Remeron it made it so I couldn't tell I was full. So I'd keep eating. I'd have to consciouslly measure out portions to avoid overeating and gaining weight.

    The drugs don't actually make you gain weight, the over-eating does. If you can manage to control that, it will be ok. It can be hard at first, but if you're aware of it before you start taking the drug it shouldn't be a problem.

    It would be like saying marijuana makes you gain weight, it doesn't, it just makes you hungry.
    Well said, @akl63. I did gain over 20 pounds over about 5 months with Zoloft, but it wasn't just magically being packed on. I was fully aware of my increased food intake. Although I have always had a relatively healthy diet, taking that med made me "care less," maybe...not entirely sure. I know I was more prone to eating not just more, but also more food that I would not usually eat regularly. Weight came off after stopping the Zoloft (oh, and the horror of the withdrawal brain zaps, despite doctor-designed taper plan, just added to my reasons for not trying it again).

    SNRIs are less likely to cause weight gain from what I understand, but the antidepressants all seem to have it listed as a potential side effect. Seems that people just respond differently to different ones and you can try to be vigilant about your diet and cravings, etc. I always thought gaining weight would counter the antidepressant mood boost, anyway. Getting fat depresses most of us, right? A very unfortunate effect that I wish docs addressed more and explained better.

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    Quote Originally Posted by akl63 View Post
    When I took Remeron it made it so I couldn't tell I was full. So I'd keep eating. I'd have to consciouslly measure out portions to avoid overeating and gaining weight.

    The drugs don't actually make you gain weight, the over-eating does. If you can manage to control that, it will be ok. It can be hard at first, but if you're aware of it before you start taking the drug it shouldn't be a problem.

    It would be like saying marijuana makes you gain weight, it doesn't, it just makes you hungry.
    Although I think for some folks, the ADs can slow their metabolism.

    But for me, Prozac and then Cymbalta took away my desire to binge eat. Now I never did buy tons of junk and then stuff it in my face in the car, like in a Lifetime movie. But I would overeat whatever we had in the house. Almonds, granola bars, crackers, whatever there was.

    So when the ADs took that desire away, I was very pleased. Now I did not lose weight as I quickly figured out between my aging and my appetite, I could just keep a better handle on my weight now.
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    Quote Originally Posted by ProfessorMoriarty View Post
    Well said, @akl63. Although I have always had a relatively healthy diet, taking that med made me "care less," maybe...not entirely sure. (
    The worst part of Antidepressant type meds is exactly what you are describing.
    APATHY

    And not just with regards to your diet, but for me my entire life. I became apathetic towards everything, didn't care one way or the other. It took me awhile once I stopped the meds, to sort of get back to "giving a shit" about anything.

    Especially with Remeron, and I was just taking that for sleep. Because my doctor was too chicken to prescribe a proper sleep med, like a quick acting benzo or a Z-drug even. I did/do much better taking Triazolam every once in awhile when I need it for sleep, with next to no side effects. I swear taking Remeron I could sleep 18 hours, and for the other 6 hours I'd be awake, eat constantly. Terrible stuff.
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    Quote Originally Posted by akl63 View Post
    The worst part of Antidepressant type meds is exactly what you are describing.
    APATHY

    And not just with regards to your diet, but for me my entire life. I became apathetic towards everything, didn't care one way or the other. It took me awhile once I stopped the meds, to sort of get back to "giving a shit" about anything.

    Especially with Remeron, and I was just taking that for sleep. Because my doctor was too chicken to prescribe a proper sleep med, like a quick acting benzo or a Z-drug even. I did/do much better taking Triazolam every once in awhile when I need it for sleep, with next to no side effects. I swear taking Remeron I could sleep 18 hours, and for the other 6 hours I'd be awake, eat constantly. Terrible stuff.
    Apathy! That is such a great way to explain it. I had not ever thought of it that way. Granted, my experience was short-term, but I do remember caring much less about normal things like getting dressed, etc. (yes, I still wore clothing , but I actually got a few comments from people about my more "relaxed" look). No, "relaxed" was not intended as a compliment. Translation: slob.

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    When I was younger I took Paxil, which I refer to as Pack-It-On Paxil
    I switched to Effexor ER and never had a problem with weight again. It also did not increase my appetitie. I haven't been on anything for about 15 years so I do ont know about the meds now.
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