Oxycodone vs. Oxymorphone

[Deuces]

Can anybody give me an estimated correlation in strength in mg between the two? IE: 100mg oxycodone=40mg oxymorphone, or something of that nature?
Also, is there any serious risk in mixing the two? As long as it's not overdone then my educated guesses say no, but I wanted to ask the smart folks around here...

[Nickel]

Taken orally Oxymorphone is roughly two times stronger than Oxycodone. If insufflated, Oxymorphone is about five times stronger than Oxycodone, something many people find out the hard way. Alcohol greatly increases the strength of Oxymorphone and pretty much throws all the charts off. IOW, don't drink alcohol if you take Oxymorphone. If there is one med you should research the living crap out of, it's Oxymorphone. Please, please be careful.

As far as mixing them, I have no idea. I would venture to guess that is a Very Bad Idea.

[Good Apollo]

Can anybody give me an estimated correlation in strength in mg between the two? IE: 100mg oxycodone=40mg oxymorphone, or something of that nature?
Also, is there any serious risk in mixing the two? As long as it's not overdone then my educated guesses say no, but I wanted to ask the smart folks around here...

I don't know the equivalency, but i had kidney stones and got percocets from ER... was back at the ER as soon as the dilauded they gave me wore off... then they gave me oxyM... omg omg omg omg that stuff is crazy strong!!! Was trying to think of a non 13 year old way to put it, but since I didn't know any factual data outside of experience, I figured that was a decent way to express it?

I recall that the doc said to take them until everything stopped hurting... which I did... felt nautious but knife in the side stopped being there a bit. I would be careful cross pilling with them though, check interactions dosage etc.

[Skeletal_Wings]

Can anybody give me an estimated correlation in strength in mg between the two? IE: 100mg oxycodone=40mg oxymorphone, or something of that nature?
Also, is there any serious risk in mixing the two? As long as it's not overdone then my educated guesses say no, but I wanted to ask the smart folks around here...

That's quite a difficult question to answer, considering that there are many more differences between Oxycodone & Opana (Oxymorphone) than a simple, straightforward, "concrete" numerical comparision could ever be able to effectively illustrate. Much more than a matter of milligram v. milligram potency, it's a matter of numerous differences in the effects of the two substances. Since every individual reacts differently to every substance (hopefully that's not news to anyone!), it's certainly no surprise that you'd always be destined to receive numerous different responses to that question, seeing as each individuals response to the question most likely was dedicated by their individual response to both Oxycodone & Opana/Oxymorphone.

All THAT said, though...

In my personal opinion (first & foremost), yet also taking other people's opinions that I've heard into mind, I'd say that either 30mg of Oxycodone equals 50mg of Oxymorphone, or that 30mg of Oxy equals 60mg of Opana.


& YES, there's actually no question that there's a very substantial risk in mixing those two drugs! You've REALLY got to be extra extra careful with Oxymorphone/Opana... every time, all the time, no matter what.

[Soho79]

That's quite a difficult question to answer, considering that there are many more differences between Oxycodone & Opana (Oxymorphone) than a simple, straightforward, "concrete" numerical comparision could ever be able to effectively illustrate. Much more than a matter of milligram v. milligram potency, it's a matter of numerous differences in the effects of the two substances. Since every individual reacts differently to every substance (hopefully that's not news to anyone!), it's certainly no surprise that you'd always be destined to receive numerous different responses to that question, seeing as each individuals response to the question most likely was dedicated by their individual response to both Oxycodone & Opana/Oxymorphone.

All THAT said, though...

In my personal opinion (first & foremost), yet also taking other people's opinions that I've heard into mind, I'd say that either 30mg of Oxycodone equals 50mg of Oxymorphone, or that 30mg of Oxy equals 60mg of Opana.


& YES, there's actually no question that there's a very substantial risk in mixing those two drugs! You've REALLY got to be extra extra careful with Oxymorphone/Opana... every time, all the time, no matter what.

Well said Skeletal Wings i couldn't have said it better.... IMO some people love Opana and some hate it, Again IMO everyone loves oxycodone, at least those who like opiates anyways )))) ..... I myself tried Opana for pm at the time of Purdue's change-over, and i didn't care for it. But it was the CR... I hear everyone likes the IR formula but iv never tried..

[billyboy1965]

Also, is there any serious risk in mixing the two? As long as it's not overdone then my educated guesses say no, but I wanted to ask the smart folks around here...

The best person to ask would be the physician who prescribed them. Doubtful that physician would have scripted them simultaneously. That in itself should answer your question.

[Deuces]

Thanks for all the answers, opinions, and warnings folks. I will be careful, as I always am... I lost my "Superman complex" awhile ago
I'd still be happy to read more input, so if you read this thread please don't take this message as me closing it...

[alumni]

it's certainly no surprise that you'd always be destined to receive numerous different responses to that question, seeing as each individuals response to the question most likely was dedicated by their individual response to both Oxycodone & Opana/Oxymorphone.

All THAT said, though...

In my personal opinion (first & foremost), yet also taking other people's opinions that I've heard into mind, I'd say that either 30mg of Oxycodone equals 50mg of Oxymorphone, or that 30mg of Oxy equals 60mg of Opana.

While I agree that comparing equipotency among any class of drugs is not very scientific, I believe you might have your math backwards in this example comparing oxymorphone to oxycodone.
Oxymorphone is clearly the more potent of the two. Thus, I've seen charts listing 30mg of oxymorphone being comparable to 60mg of oxycodone on a mg to mg basis, not the other way around.
I've also seen 30mg of oxymorphone shown equipotent to 100mg of oxycodone and even one showing 30:180.
But definitely 60mg of Opana is NOT equipotent to 30mg oxycodone. That would be a very dangerous mistake in conversion.

[divide_by_zero]

Oxymorphone is definitely the stronger of the two. In vivo a small fraction of oxycodone is metabolized into oxymorphone. This is important because the expression of the enzyme responsible for that conversion is significantly variable. Hydrocodone is also affected in this way, being metabolized into hydromorphone, making both kind of like pro-drugs. Obviously hydrocodone and oxycodone have their own analgesic properties.

So you can't easily quantify what % of oxycodone is metabolized to oxymorphone, you will be able to better gauge the equivalency if you allow most of the -codone to leave your body, and then taking a safe, accurate dose of -morphone. Get the rough equivalencies that are in the literature, and then dose a little less the first time. That's what I'd do.

[MidnightRambler]

I am new to this forum and I have been looking for something to post on that I have some knowledge about. I am an experienced opiate user and I have indeed mixed oxycodone and oxymorphone. There is always a danger in using ANY opiates but there is no added danger in mixing the two. One poster above said that oxymorphone is approximately 2x as strong as oxycodone which I have found to be true. He said 5x as strong when insufflated which I did not find to be true but perhaps he has more knowledge then I. From my personal experience the 2x rule holds true no matter if insufflated or eaten. The only danger in mixing the two is the same danger in taking to much of any kind of opiate, nothing more, nothing less.

[johndoepoe]

@MidnightRambler

No disrespect I hope; but there is a danger in mixing the two. I think the half life could be different depending on how you take the drugs. The onset also; depending on how you take it. Really, there is no need to mix the two of them.

[Nickel]

I am new to this forum and I have been looking for something to post on that I have some knowledge about. I am an experienced opiate user and I have indeed mixed oxycodone and oxymorphone. There is always a danger in using ANY opiates but there is no added danger in mixing the two. One poster above said that oxymorphone is approximately 2x as strong as oxycodone which I have found to be true. He said 5x as strong when insufflated which I did not find to be true but perhaps he has more knowledge then I. From my personal experience the 2x rule holds true no matter if insufflated or eaten. The only danger in mixing the two is the same danger in taking to much of any kind of opiate, nothing more, nothing less.

I think Opana tends to confuse people who are used to Oxycodone. Opana comes on much slower, with much less of an onset "rush" and there is a tendency to think it's not working. My 5X stronger comment when insufflated is from personal experience. That takes into account the tremendous legs Opana has and the devilsh way it interacts with alcohol and benzos...even food can hugely intensify the effects. But then everyone is different and I've read cases of people barely feeling it. I've also heard cases of people using the 2X rule and spending the night puking into a toilet and falling down. Compared to Opana, I don't find Oxycodone that strong, dose for dose. In the end, just start very slowly and find out how it affects you.

[dannyboy868]

Yea-- My friend used to take opana's and loved them. Supposedly they are insanely strong. Some people say that Oxycodone is better, but i disagree. I was on opana for a stint and they are very strong.

But like they say, be insanely careful. My best friend ace got carried away and ate 3, then snorted one of the 40 mg ones (the highest potency pill they sell) he almost died. His wife found him on the floor blue and called the ambulance. Said he barely pulled through.

Remember with opiates, you can always put more in, but never take it out. Use caution, know your tolerance, limits, etc. Dont become another statistic dead of an opiate overdose. Enjoy. Daniel

[alumni]

With opioids, overdose is overdose regardless of which drugs are involved.
That's why self-medicating with them can be deadly even when the user has convinced himself that he "knows what he's doing."
Mixing and matching, snorting, chewing ER meds, shooting, etc. anything other than taking basically as prescribed is always going to be a risk. Add to that a polydrug mix (including alcohol) and there's really no telling what the result is going to be.
Witness the prior confusion of drug strength by @Skeletal_Wings as a good example.

[Good Apollo]

With opioids, overdose is overdose regardless of which drugs are involved.
That's why self-medicating with them can be deadly even when the user has convinced himself that he "knows what he's doing."
Mixing and matching, snorting, chewing ER meds, shooting, etc. anything other than taking basically as prescribed is always going to be a risk. Add to that a polydrug mix (including alcohol) and there's really no telling what the result is going to be.
Witness the prior confusion of drug strength by @Skeletal_Wings as a good example.

And since the ceiling on oxymorphone is very high, mixing is extra specially more dangerous, because a person will keep feeling more and more effect, and next thing one knows the entire bottle is emptied in 6 hours and youre dead. Be careful. If you need to mix OxyC and OxyM, and I mean NEED not just are doing for fun, well that person needs some help either way... pls be careful.

[Va2323]

oxymorphone is very strong but i dont agree that its that much stronger then oxycodone it is stronger but not by the ratios stated above, i do have a high tolerance to pain meds but that my opinion.

[alumni]

While that may be your opinion, the research that has gone into compiling these opioid equivalency comparisons clearly doesn't agree.
As I said previously, these averages estimate that oxymorphone can be anywhere from 100% to 600% more potent than oxycodone via PO administration.
User beware.

[beenawhile]

I have been on oxy(contin&codone) for 4 years. I am thinking of switching to Opana. I'm in FL, and have been haveing a terrible time getting my script filled suddenly 4 months ago (others in my area started reporting this a few months before me,guees I got lucky for a bit, that ended, and i could tell that there was something in the FL database that had me flagged,now, there is no reason i can think of I would have been flagged except that my wife was on vicodin for a few months and I heard the database would kick out if you went for Oxy, and anyone with your address has gotten pain meds lately, dont know what latelt means). I posted all of this to explain what my situation is, I'm not looking for "this is better than that"I see & appreciate those posts, wondering about the pharmacy issue. has anyone tried the switch for this reason? how did it work out? Thanks

[Nickel]

oxymorphone is very strong but i dont agree that its that much stronger then oxycodone it is stronger but not by the ratios stated above, i do have a high tolerance to pain meds but that my opinion.

@Va2323, it's a valid opinon. I rate Opana so high because of its unpredictability. With oxycodone, a patient can pretty much predict the results. Opana is such a wild card though. Sneaky, heavy body load that comes on a bit slow. Food, alcohol, other meds... so many things can amplify it's effects tremendously. Dangerously. Uncomfortably. In comparison, oxycodone is more predictable.

[dingleberry]

Be careful with the Opana, yes its very strong, I personally dispute the fact that it is stronger than oxy orally (effects wise) orally does verry little for me compared to oxy in equatable doses, but in regard to alternate ROA's it can be overwhelmingly potent so use caution I dont advocate abuse of any substance in terms of using it in any way besides its intended use, but just wanted to clarify oral admin of opana is usually a let down for many expecting a similar or stronger effect in comparison to oxy effect, but make no mistake this substance is something to be treated with much respect and even fear in some ways it is unique and overwhelmingly potent in ways that are hard to describe. Do not ever try to IV this substance, it is not only unhealthy but is very dangerous. People need to do their research before even considering using this chemical. In most cases I would advise avoid opana for most people especially if they are prone to abuse of any substances or have that in their history.