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Thread: How does aspirin and acetaminophen (Tylenol) reduce fever in the body?

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    Default How does aspirin and acetaminophen (Tylenol) reduce fever in the body

    How does aspirin and acetaminophen (Tylenol) reduce fever in the body?

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    Aspirin reduce fever (and pain) in the body by suppressing the production of prostaglandins and thromboxanes. Its main mechanism of action is irreversible inactivation of the cyclooxygenase (COX) enzyme which is the parent enzyme of prostaglandin & thromboxane.

    The mechanism by which paracetamol (acetaminophen) reduces fever and pain is still a source of debate. The reason for this confusion has largely been due to the fact that paracetamol reduces the production of prostaglandins—pro-inflammatory chemicals. Aspirin also inhibits the production of prostaglandins, but, unlike aspirin, paracetamol does not have much anti-inflammatory action. Likewise, whereas aspirin inhibits the production of the pro-clotting chemicals thromboxanes, paracetamol does not. Aspirin is known to inhibit the cyclooxygenase (COX) family of enzymes, and, because of paracetamol's partial similarity of aspirin's action, much research has focused on whether paracetamol also inhibits COX.

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    Thanks, this really helps!

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    Quote Originally Posted by got me tickin' View Post
    How does aspirin and acetaminophen (Tylenol) reduce fever in the body?
    Antipyretics (fever reducing drugs) cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever.

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