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My Great Pyrenees/Samoyed mix had a peri-anal fistula. After researching everything, we went for the cyclosporine. We were told that our options were removing her tail & the anal gland causing the problem, as big dogs with heavy, hanging tails are prone to this, or cyclosporine. Removing anal gland CAN cause an incontinence problem, according to the specialist we saw, and we feel that removing the tail is cruel-plus we were told that isn't a fool-proof way to help the problem. We went for the cyclosporine, & tho costly, it WORKED! We had one relapse that antibiotics helped, but the cyclosporine did the job and we'd go that route again if we were faced with this issue again.
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