The first report on an autoimmune disease, paroxysmal cold hemoglobinuria, was published by Julius Donath and Karl Landsteiner in 1904. But it was not until the second half of the 20th century that research on the detection and analysis of autoantibodies provided useful new possibilities in the diagnosis of autoimmune diseases and that the improved understanding of tolerance and T-cell regulation allowed better insights into their pathogenesis.
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