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There are many possible causes of throat spasm. If it usually occurs at night, it might me COPD, so I would prefer to see a specialist to rule that out. It can also be caused by chronic conditions of various parts of the nervous-system, it can be set off by anything that causes muscle spasms (in both smooth and striated muscles). In that case, muscle relaxants like Flexeril can be used. If the throat spasm is accompanied by acid reflux and hiatal hernia, hyoscyamine can be given instead.
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