@
overtherainbow
Interesting Dx you had.
I know that we have one way valves in our lower extremities that are easily dysfunctional from sitting and being sedentary. The valves allow the blood to return to the heart, veinous flow as opposed to arterial. These valves are like this:
Showing healthy and non -- (some variations of this can happen as well of course)
http://www.carolinaveincenter.com/css/images/duplex.jpg
With these dysfunction swelling, 'varicose' appearance, and general pooling of blood is common. This pooling can cause swelling many times, due to capillary leaking through the dermis layers. (Similar principle to swollen eye bags, and the rings .. (sorry best example I could think of at the time

).
But, these are mostly superficial.
Now more symptomatic is what is known as PAD, or peripheral artery disease. I've seen this quite a bit in school. It is the same process that effects the heart and surrounding the periocardium vicinity of valves.
For example:
http://hearthealthywomen.org/images/PVD/pad_plaque.jpg
This could be something similar in these conditions.
though
@
Chanel
still sounds and presents very much neuro related.. (not brain) but innervation through the leg, perhaps from lower back.. or even the leg itself from the swelling.
If you find out soon, please let us know.