
Originally Posted by
bradleyolson
Taking a benzodiazepine (Klonopin, Xanax, et cetera) while on the come-down from a stimulant dose (Adderall, Ritalin, Vyvnase, et cetera) isn't likely to cause you any problems, provided that you ensure the two drugs are taken at least several hours apart. Taking a benzodiazepine in combination with a stimulant (simultaneously) is not, however, recommended (without the advice of a medical professional).
Someone mentioned here that taking a benzodiazepine/depressant and a stimulant together would likely cause a decrease in the effects of each, and this is most certainly incorrect. It is a wide-spread falacy (particularly among the recreational drug-using community) that depressants will decrease the risks or side-effects from stimulant use, and likewise, that stimulants will decrease the risks/side-effects from depressant use. Taking central nervous system (CNS) stimulants together with CNS depressants can cause increased stress to the heart, including heart failure, as well as increased risk of psychosis and paradoxical reactions.
If the effects of stimulants and depressants were to cancel each other out, so to speak, not only would they be used medically as antidotes for overdoses from each other, but their combination would not be sought-after by recreational drug users (think speed-ball).
There are some rare situations where, if seeking professional medical help is absolutely not an option, depressants may be indicated immediately following or during the acute effects of stimulants, but that is beyond the scope of this thread.
Back to the original question though (sorry, I sometimes get off topic); taking a depressant (benzodiazepine) hours after using a stimulant (like Adderall) isn't known to carry a high risk. Doctors will sometimes prescribe depressants (including benzodiazepines) in the event that a prescribed stimulant taken earlier in the day causes insomnia in the evening. They may also, very rarely however, be prescribed together for some very specific indications (refractory treatment-resistant social anxiety disorder w/ agoraphobia, or concomitant adult AD[H]D and panic disorder, for instance), but in these instances the patient would be monitored very closely by their physician. Benzodiazepines and stimulants are used safely together, but due to the risk of certain side effects, medical oversight by a professional is strongly recommended.