Benzos half-life (duration)

[Perromaldido]

I saw a lot of posts asking about half life of bdp's. Here's what I got from a good italian site which lists half life range (emivita) of the more coomon ones. Trade names refer to italian brands and obviously may be different than the ones in your country. As you can see on the hypnotic side flunitrazepam beats the shit out of others. I see that Nitrazepam (mogadon) is missing. I'd place it in the same range of fluni though it's definily not as strong as.

■Diazepam (Valium, Ansiolin, Tranquirit, Noan)
■Delorazepam o Clordemetildiazepam (En)
■Clordiazepossido (Librium)
■Flurazepam (Dalmadorm, Flunox).

Emivita compresa tra 24 e 48 ore:

■Bromazepam (Lexotan, Compendium)
■Clotiazepam (Tienor, Rizen)
■Flunitrazepam (Darkene, Roipnol).

Emivita minore di 24 ore:

■Alprazolam (Xanax, Frontal, Valeans, Mialin)
■Lorazepam (Tavor, Control, Lorans, Ativan e Trapax)
■Lormetazepam o Metillorazepam (Noctamid, Minias)
■Oxazepam (Serpax, Limbial)
■Clotiazepam (Rizen, Tienor)
■Ketazolam (Anseren).

Emivita da 1 a 7 ore

■Brotizolam (Lendormin)
■Midazolam (Ipnovel, Dormicum)
■Triazolam (Halcion, Songar)
■Etizolam (Depas, Pasaden).

Perromaldido

[alumni]

My Italian is a little rusty but is this chart indicating that Valium and Librium have similar half-life elimination rates?
I can't tell from your post what the time period is for them but it's very doubtful that they would have a comparable estimated half-life except possibly when measuring how long their metabolites could be detected.
Just as an aside, there are much more extensive and detailed charts available in publications and on the Internet if you are really interested in this type of pharmaceutical data.
Buona sera

[Perromaldido]

Grazie @alumni . In between 48 and 24 hrs there's....one day. You know, same old subjective dose responseness issue. I forgot to translate those few lines but I guess it's clear for all now. Actually I rate the site I took this info from good. The Ashton manual
-AFAIR- is not looking at that in a different way. But if you could point me/us to a more comprehensive and a more accurate half range life considered table I'd be interested.

Perromaldido

[alumni]

There are lots of them including Dr. Ashton's at benzo.org.uk
While I'm usually leery about anything written on wikipedia, the chart they use is somewhat detailed and factual.
On this subject, though (along with pharmacy textbooks), I often refer to both a Canadian web site vhpharmsci.com and US-based psychresidentonline.com
Also, I believe Dr. Ashton would disagree with estimating that Librium and Valium have approximately the same rates of elimination.

[etinin]

Valium is eliminated more slowly. It seems to be more lipossoluble than chlordiazepoxide. Both are mostly metabolized to desmethyldiazepam, though. So, in the long term, it doesn't make a big difference, especially if chronically used.

[Perromaldido]

''Codein's patient information - Side effects: ... False sense of well-being."

LOL at that!

Perromaldido

[audacity]

Half-life has little to do with subjective duration of effects. Half-life usually means plasma level half-life; the amount in the blood plasma, not the amount the in brain. For example, Valium and its active metabolites have a very long half life, but doesn't last as long as you might think. Ativan has a short half-life, but lasts pretty decent considering its short half life and no active metabolits. That's because Valium is very lipophilic and reaches the brain quickly, but then equilbriates with the blood plasma pretty quickly after that (aka redistribution). Ativan doesn't have such a severe redistribution because of its lower lipophilicity.

[etinin]

Half-life has little to do with subjective duration of effects. Half-life usually means plasma level half-life; the amount in the blood plasma, not the amount the in brain. For example, Valium and its active metabolites have a very long half life, but doesn't last as long as you might think. Ativan has a short half-life, but lasts pretty decent considering its short half life and no active metabolits. That's because Valium is very lipophilic and reaches the brain quickly, but then equilbriates with the blood plasma pretty quickly after that (aka redistribution). Ativan doesn't have such a severe redistribution because of its lower lipophilicity.

That's true as well. Valium is also highly protein bound, which greatly reduces its distribution half-life. That means that its quickly spread thorough the body. That's why it's only effective for approximately 15min when employed against seizures.

Looking at your display picture reminds me that last night I tried some Dormonid (a Roche branded Midazolam) and it was a little weird. After like two or three hours I woke up (though I was able to get back to sleep).

[off]

''Codein's patient information - Side effects: ... False sense of well-being."

LOL at that!

Perromaldido

Yeah, laughed a lot too when I first bought this brand of codeine and read the patient information leaflet xD
Truth is that it's often the intended effect of the medication for many patients