GHB for alcoholism? That doesn't seem to be pretty effective?
Originally Posted by Perromaldido
First: sodium oxybate & GHB are the same substances.. although i think you were stating that; just trying to clarify things.
Second: GHB has a very short duration of action (in fact, it usually requires 24-7 dosing to maintain a dependency, i would think this would include a detox), & we know that longer duration of action drugs are better for detox and/or maintenance therapy (diamorphine/heroin vs. methadone or buprenorphine?), as the withdrawal from a short-duration psychoactive is much harsher & intense. If a taper is done properly? Withdrawal from a longer acting psychoactive replacement drug can be next to non-existent! (I weaned off of buprenorphine, 8mg/day, but had to go back on it for pain reasons; as i can't rationally take the PRESCRIBED DOSES of full-agonist opioids!)
Third: while producing similar effects, GABA-a positive-modulators (alcohol, benzodiazepines, barbiturates, etc) & GABA-b agonists (GHB, GVL, other GHB-analogs, additionally baclofen & phenibut) are absolutely not cross tolerant.. in fact, one is a ionotropic-type-receptor (GABA-a) & the other (GABA-b) functions oppositely as a metabotropic receptor, depending on eukaryotic cells & on G-coupled proteins as ligands for neurotransmission (i.e., think of these "ligands" as an intermediate neurological entities, between the drug's initial introduction to the receptor complex & the final neurotransmitter release or modulation resulting in psychotropic effects).
I know this from personal experience (barbiturate vs. baclofen- both very specific for GABA-a & GABA-b receptors, respectively); so withdrawal symptoms would not be completely resolved when using a GABA-b agonist for dependency upon a GABA-a positive modulator. As explained, they're two completely different receptors (forget the "GABA" commonality for a moment) & function.. err.. modulate GABA (or "change how GABA acts" to state it more simply) via two completely different mechanisms.
Although ethanol is sort of a loose cannon.. Of course no pharmaceutical company will invest in discovering its actual in vivo pharmacological action (although it is highly suspected to act at GABA-a benzodiazepine binding sites, along w/ dopamine & a myriad of other receptor-complexes.. which make the sh*t "dirty" in my opinion) since there is no money to be made by PhRMA... can't patent it to recoup the funds invested in the three trials of the FDA for approval for pharmaceutical sale... which, of course, the FDA wont approve any form of ethanol anyway as it is specifically singled-out to be regulated by the ATF. Any ethanol "patents" would be for booze-formulations, not nearly as profitable as a name-brand medication fully approved by the FDA.
Last edited by MusiciansMallet; 06-08-2013 at 10:58 AM.
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